N-bromoacetyl-D-leucylglycine. An affinity label for neutral endopeptidase 24.11.

Article

N-bromoacetyl-D-leucylglycine. An affinity label for neutral endopeptidase 24.11.

The Journal of biological chemistry - 25 May 1990

Bateman R C, Kim Y A, Slaughter C, Hersh L B

Abstract excerpt

Neutral endopeptidase 24.11 is rapidly inactivated by N-bromoacetyl-D-leucylglycine in a reaction which follows first-order kinetics at pH 8 and 37 degrees C. The concentration dependence of inactivation revealed saturation kinetics with an apparent Ki of 10 mM and kappa inact of 0.4 min-1 at sat...

Topics

Affinity Labels
Animals
Base Sequence
Cell Membrane
Dipeptides
Enkephalin, Leucine
Kidney
Kinetics
Molecular Sequence Data
Mutation
Neprilysin
Oligonucleotide Probes
Rats

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