Article
Binding properties of a highly potent and selective iodinated aminopeptidase N inhibitor appropriate for radioautography.
FEBS letters - 4 Feb 2000
Noble F, Luciani N, Da Nascimento S, Laï-Kuen R, Bischoff L, Chen H, Fournié-Zaluski M C, Roques B P
Abstract excerpt
Aminopeptidase N (APN) is a zinc metallopeptidase involved in the inactivation of biologically active peptides. The knowledge of its precise distribution is crucial to investigate its physiological role. This requires the use of appropriate probes such as the recently developed highly potent and selective radiolabeled APN inhibitor 2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-3-[ (12...
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