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Article

Cystic fibrosis CFBE41o- cells contain TLR1 SNP I602S and fail to respond to Mycobacterium abscessus.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Dec 2013

Kempaiah Prakasha, Davidson Lisa B, Perkins Douglas J, Byrd Thomas F

Abstract excerpt

BACKGROUND: Mycobacterium abscessus causes lung infection in patients with cystic fibrosis. M. abscessus stimulates the host innate immune response via TLR2 on respiratory epithelial cells. Signaling through TLR2 requires the formation of TLR2/TLR1 heterodimers on the cell surface. METHODS: The ability of M. abscessus to stimulate the innate immune response of cystic fibrosis CFBE41o- respiratory epithelial cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23403223
DOI: 10.1016/j.jcf.2013.01.001
PMCID: PMC4712101

Genes

TLR2
TLR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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