Article
Combined analysis of circulating β-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects.
Molecular brain - 12 Feb 2013
Rhodin Annica, Grönbladh Alfhild, Ginya Harumi, Nilsson Kent W, Rosenblad Andreas, Zhou Qin, Enlund Mats, Hallberg Mathias, Gordh Torsten, Nyberg Fred
Abstract excerpt
BACKGROUND: Opioids are associated with wide inter-individual variability in the analgesic response and a narrow therapeutic index. This may be partly explained by the presence of single nucleotide polymorphisms (SNPs) in genes encoding molecular entities involved in opioid metabolism and receptor activation. This paper describes the investigation of SNPs in three genes that have a functional impact on the opioid...
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