Article
Biological and clinical significance of KRAS mutations in lung cancer: an oncogenic driver that contrasts with EGFR mutation.
Cancer metastasis reviews - 1 Mar 2010
Suda Kenichi, Tomizawa Kenji, Mitsudomi Tetsuya
Abstract excerpt
KRAS and epidermal growth factor receptor (EGFR) are the two most frequently mutated proto-oncogenes in adenocarcinoma of the lung. The occurrence of these two oncogenic mutations is mutually exclusive, and they exhibit many contrasting characteristics such as clinical background, pathological features of patients harboring each mutation, and prognostic or predictive implications. Lung cancers harboring the EGFR...
Topics
- Adenocarcinoma
- Animals
- Cell Transformation, Neoplastic
- Gene Expression Regulation, Neoplastic
- Genes, erbB-1
- Genes, ras
- Humans
- Lung Neoplasms
- Models, Biological
- Mutation
- Transcriptional Activation