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Article

HLA class I expression and chromosomal deletions at 6p and 15q in head and neck squamous cell carcinomas

1 Sept 1999

Abstract excerpt

Loss at the chromosomal region 6p21.3 is a frequent event in head and neck squamous cell carcinomas (HNSCC). Since the human leukocyte antigen (HLA) complex is located at 6p21.3, loss of heterozygosity (LOH) of this region may provide tumour cells with an immune-escape tumour phenotype. In the present study, we have studied the correlation of HLA class I, TAP1 and TAP2 expression and LOH at 6p21.3. HLA class I...

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Identifiers

PMID: 10519360
DOI: 10.1034/j.1399-0039.1999.540304.x

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