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Article

Oroxylin A suppresses ACTN1 expression to inactivate cancer-associated fibroblasts and restrain breast cancer metastasis.

Pharmacological research - 1 Sept 2020

Cao Yue, Cao Wangjia, Qiu Yangmin, Zhou Yuxin, Guo Qinglong, Gao Yuan, Lu Na

Abstract excerpt

Tumor initiation and progression are not only ascribed to the behavior of cancer cells, but also profoundly influenced by the tumor microenvironment. Inside, cancer-associated fibroblasts (CAFs) have become key factors to accelerate growth and metastasis for the abundance in most solid tumors. Our group previously reported that Oroxylin A (OA), a flavone from Scutellaria Baicalensis Georgi, possess the ability to...

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Identifiers

PMID: 32492489
DOI: 10.1016/j.phrs.2020.104981

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