A novel human S10F‐Hsp20 mutation induces lethal peripartum cardiomyopathy

Abstract excerpt

Heat shock protein 20 (Hsp20) has been shown to be a critical regulator of cardiomyocyte survival upon cardiac stress. In this study, we investigated the functional significance of a novel human Hsp20 mutation (S10F) in peripartum cardiomyopathy. Previous findings showed that cardiac-specific overexpression of this mutant were associated with reduced autophagy, left ventricular dysfunction and early death in male...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiac Structural Anomalies and Repair
• Share to Cardiovascular Issues in Pregnancy
• Share to Pulmonary Hypertension Research and Treatments