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Article

NDP52, a novel autophagy receptor for ubiquitin-decorated cytosolic bacteria

16 Feb 2010

Abstract excerpt

Autophagy functions as a cell-autonomous effector mechanism of innate immunity by separating bacteria from cytosolic resources and delivering them for lysosomal destruction. How cytosolic bacteria are targeted for autophagy is incompletely understood. We recently discovered that Salmonella enterica serotype Typhimurium and Streptococcus pyogenes are detected by NDP52 (nuclear dot protein 52 kDa), after these...

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PMID: 20104023
DOI: 10.4161/auto.6.2.11118

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