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Article

Using steered molecular dynamics to predict and assess Hsp70 substrate-binding domain mutants that alter prion propagation.

PLoS computational biology - 1 Jan 2013

Xu Linan, Hasin Naushaba, Shen Manli, He Jianwei, Xue Youlin, Zhou Xiaohong, Perrett Sarah, Song Youtao, Jones Gary W

Abstract excerpt

Genetic screens using Saccharomyces cerevisiae have identified an array of cytosolic Hsp70 mutants that are impaired in the ability to propagate the yeast [PSI(+)] prion. The best characterized of these mutants is the Ssa1 L483W mutant (so-called SSA1-21), which is located in the substrate-binding domain of the protein. However, biochemical analysis of some of these Hsp70 mutants has so far failed to provide...

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Identifiers

PMID: 23382668
DOI: 10.1371/journal.pcbi.1002896
PMCID: PMC3561046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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