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Article

Precise SDF1-mediated cell guidance is achieved through ligand clearance and microRNA-mediated decay.

The Journal of cell biology - 4 Feb 2013

Lewellis Stephen W, Nagelberg Danielle, Subedi Abhi, Staton Alison, LeBlanc Michelle, Giraldez Antonio, Knaut Holger

Abstract excerpt

During animal development, SDF1 simultaneously guides various cell types to different targets. As many targets are in close proximity to one another, it is unclear how the system avoids mistargeting. Zebrafish trigeminal sensory neurons express the SDF1 receptor Cxcr4b and encounter multiple SDF1 sources during migration, but ignore all but the correct one. We show that miR-430 and Cxcr7b regulation of SDF1a are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23382464
DOI: 10.1083/jcb.201207099
PMCID: PMC3563679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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