Article
A chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal axon pathfinding.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Feb 2003
Chalasani Sreekanth H, Sabelko Kimberly A, Sunshine Mary J, Littman Dan R, Raper Jonathan A
Abstract excerpt
Altering the concentrations of cyclic nucleotides within nerve cells can dramatically change their responses to axonal guidance cues, but the physiological signals that might induce such alterations are unknown. Here we show that the chemokine stromal cell-derived factor 1 (SDF-1) reduces the repellent activities of slit-2 on cultured retinal ganglion cell axons, of semaphorin 3A on dorsal root ganglion sensory...
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