Article
Should all BRCA1 mutation carriers with stage I breast cancer receive chemotherapy?
Breast cancer research and treatment - 1 Feb 2013
Narod Steven A, Metcalfe Kelly, Lynch Henry T, Ghadirian Parviz, Robidoux Andre, Tung Nadine, Gaughan Elizabeth, Kim-Sing Charmaine, Olopade Olufunmilayo I, Foulkes William D, Robson Mark, Offit Kenneth, Jakubowska Ania, Byrski Tomasz, Huzarski Tomasz, Sun Ping, Lubinski Jan
Abstract excerpt
To estimate the 15-year survival following a diagnosis of stage I breast cancer among women who carry a BRCA1 mutation and to determine predictors of mortality, including the use of chemotherapy. Patients were 379 women with stage I breast cancer for whom a BRCA1 mutation had been identified, in herself or in a close family member. Patients were followed for up to 15 years from the initial diagnosis of breast...
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