Circumvention of multidrug resistance in P388 murine leukemia cells by a novel inhibitor of cyclic AMP-dependent protein kinase, H-87.

doi:10.1016/0304-3835(90)90228-p

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Article

Circumvention of multidrug resistance in P388 murine leukemia cells by a novel inhibitor of cyclic AMP-dependent protein kinase, H-87.

Cancer letters - 15 May 1990

Miyamoto K, Wakusawa S, Nakamura S, Koshiura R, Otsuka K, Naito K, Hagiwara M, Hidaka H

Abstract excerpt

A newly synthesized compound, H-87, N-[2-(p-bromo cinnamylmethylamino)ethyl]-5-isoquinolinesulfonamide was found to be a potent and selective inhibitor of cyclic AMP-dependent protein kinase. The effects of H-87 on in vitro sensitivities of various P388 murine leukemia cell lines resistant to several antitumor agents were examined. H-87 significantly potentiated the cytotoxic effects of Adriamycin (ADR),...

Topics

Animals
Antineoplastic Combined Chemotherapy Protocols
Biological Transport
Doxorubicin
Drug Interactions
Drug Resistance
Female
Isoquinolines
Leukemia P388
Leukemia, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred Strains

Phenotype

Protein Kinase Inhibitors

Sulfonamides

Tumor Cells, Cultured

Vinblastine

Source

Open in PubMed

Identifiers

PMID: 2337896
DOI: 10.1016/0304-3835(90)90228-p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2337896-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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