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Article

Tale of a Tegument Transactivator: The Past, Present and Future of Human CMV pp71

1 Sept 2012

Abstract excerpt

Herpesviruses assemble large virions capable of delivering to a newly infected cell not only the viral genome, but also viral proteins packaged within the tegument layer between the DNA-containing capsid and the lipid envelope. In this review, we describe the tegument transactivator of the β-herpesvirus human CMV, the pp71 protein. We present the known mechanistic features through which it activates viral gene...

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PMID: 23378857
DOI: 10.2217/fvl.12.86

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