Article
Aggregation of Platelets and Human EGFR Mutant Lung Adenocarcinoma Cells Under Flow Is Governed by Shear Accumulation.
Microcirculation (New York, N.Y. : 1994) - 1 Jan 2026
Sun Xiaoxi, Fang Xiang, Fang Ying, Wu Jianhua, Lin Jiangguo
Abstract excerpt
BACKGROUND: Circulating tumor cells (CTCs) utilize platelets to withstand hemodynamic stress and evade immune clearance; however, the mechanisms driving platelet-cancer cell aggregation under flow remain unclear. OBJECTIVE: We investigated which physical quantity-shear rate, exposure time, or an integrated metric-governs the aggregation and identified the key adhesion molecules involved. METHODS: Human platelets...
Topics
Join the communities discussing this publication.