Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aggregation of Platelets and Human EGFR Mutant Lung Adenocarcinoma Cells Under Flow Is Governed by Shear Accumulation.

Microcirculation (New York, N.Y. : 1994) - 1 Jan 2026

Sun Xiaoxi, Fang Xiang, Fang Ying, Wu Jianhua, Lin Jiangguo

Abstract excerpt

BACKGROUND: Circulating tumor cells (CTCs) utilize platelets to withstand hemodynamic stress and evade immune clearance; however, the mechanisms driving platelet-cancer cell aggregation under flow remain unclear. OBJECTIVE: We investigated which physical quantity-shear rate, exposure time, or an integrated metric-governs the aggregation and identified the key adhesion molecules involved. METHODS: Human platelets...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma of Lung
Share to Blood Platelets

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CD40 Ligand

Share to ErbB Receptors

Share to Neoplastic Cells, Circulating

Share to P-Selectin

Share to Platelet Aggregation

Share to Stress, Mechanical

Source

Identifiers

PMID: 41474549
DOI: 10.1111/micc.70047

Genes

PC
EGFR
CD40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aggregation of Platelets and Human EGFR Mutant Lung Adenocarcinoma Cells Under Flow Is Governed by Shear Accumulation.PMID 41474549Read ↗

Fluid shear stress regulates the survival of circulating tumor cells via nuclear expansionSemantic proximity Read ↗

Shear Stress-Induced Pre-Cytokinetic Block: A New Cellular Response Revealed by an Innovative Shear Stress GeneratorSemantic proximity Read ↗

Photoconversion and chromatographic microfluidic system reveals differential cellular phenotypes of adhesion velocity versus persistence in shear flow.Semantic proximity Read ↗

Definitions in biorheology: cell aggregation and cell adhesion in flow. Recommendation of the Scientific Subcommittee on Biorheology of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis.Semantic proximity Read ↗

Analyzing Mechanisms of Metastatic Cancer Cell Adhesive Phenotype Leveraging Preparative Adhesion Chromatography Microfluidic.Semantic proximity Read ↗

Single-cell imaging and transcriptomic analyses of firm adhesion between patient-derived cancer and endothelial cells under shear stressSemantic proximity Read ↗

The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer ProgressionSemantic proximity Read ↗

Fluid Shear Stress Induces EMT of Circulating Tumor Cells via JNK Signaling in Favor of Their Survival during Hematogenous Dissemination.Semantic proximity Read ↗

Tumor-Educated-Platelets interact with Breast Cancer-Stem-Cells via P-selectin- PSGL1 and ensure stemness and metastasis through WNT-β-Catenin-VEGF-VEGFR2 intra-cellular signaling: Therapeutic modulation by aspirinSemantic proximity Read ↗

Shear-Mediated Platelet Microparticles Demonstrate Phenotypic Heterogeneity as to Morphology, Receptor Distribution, and Hemostatic FunctionSemantic proximity Read ↗

Technical Advance: Changes in neutrophil migration patterns upon contact with platelets in a microfluidic assay.Semantic proximity Read ↗

Microparticle Phosphatidylserine Mediates Coagulation: Involvement in Tumor Progression and MetastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.