Article
ER stress response induced by the production of human IL-7 in rice endosperm cells.
Plant molecular biology - 1 Mar 2013
Kudo Kyoko, Ohta Masaru, Yang Lijun, Wakasa Yuhya, Takahashi Sakiko, Takaiwa Fumio
Abstract excerpt
Rice seed has been used as a production platform for high value recombinant proteins. When mature human interleukin 7 (hIL-7) was expressed as a secretory protein in rice endosperm by ligating the N terminal glutelin signal peptide and the C terminal KDEL endoplasmic reticulum (ER) retention signal to the hIL-7 cytokine to improve production yield, this protein accumulated at levels visible by Coomassie Brilliant...
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