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Article

CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma.

Cancer research - 1 Apr 2013

Ooi Aikseng, Dykema Karl, Ansari Asif, Petillo David, Snider John, Kahnoski Richard, Anema John, Craig David, Carpten John, Teh Bin-Tean, Furge Kyle A

Abstract excerpt

Sustained activation of the stress-regulated transcription factor NRF2 (NFE2L2) is a prominent feature of many types of cancer, implying that mutations driving NRF2 may be important to tumor progression. In hereditary type 2 papillary renal cell carcinoma (PRCC2, also known as hereditary leiomyomatosis and renal cell cancer), NRF2 activation is a direct consequence of the accumulation of intracellular fumarate, a...

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Share to Carcinoma, Renal Cell
Share to Cullin Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoenzyme Techniques

Share to Kelch-Like ECH-Associated Protein 1

Share to Kidney Neoplasms

Share to Kidney Tubules, Proximal

Share to NF-E2-Related Factor 2

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Source

Identifiers

PMID: 23365135
DOI: 10.1158/0008-5472.CAN-12-3227

Genes

CUL3
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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