Article
An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma.
Cancer cell - 18 Oct 2011
Ooi Aikseng, Wong Jing-Chii, Petillo David, Roossien Douglas, Perrier-Trudova Victoria, Whitten Douglas, Min Bernice Wong Hui, Tan Min-Han, Zhang Zhongfa, Yang Ximing J, Zhou Ming, Gardie Betty, Molinié Vincent, Richard Stéphane, Tan Puay Hoon, Teh Bin Tean, Furge Kyle A
Abstract excerpt
Fumarate hydratase (FH) mutation causes hereditary type 2 papillary renal cell carcinoma (PRCC2). The main effect of FH mutation is fumarate accumulation. The current paradigm posits that the main consequence of fumarate accumulation is HIF-α stabilization. Paradoxically, FH mutation differs from other HIF-α stabilizing mutations, such as VHL and SDH mutations, in its associated tumor types. We identified that...
Topics
Join the communities discussing this publication.