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Processing of Nonconjugative Resistance Plasmids by Conjugation Nicking Enzyme of Staphylococci

5 Jan 2016

Abstract excerpt

UNLABELLED: Antimicrobial resistance in Staphylococcus aureus presents an increasing threat to human health. This resistance is often encoded on mobile plasmids, such as pSK41; however, the mechanism of transfer of these plasmids is not well understood. In this study, we first examine key protein-DNA interactions formed by the relaxase enzyme, NES, which initiates and terminates the transfer of the multidrug...

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Identifiers

PMID: 26728193
DOI: 10.1128/jb.00832-15

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