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Comparative analysis of ARID1A mutations with mRNA levels and protein expression in gastric carcinoma.

Pathology, research and practice - 1 Mar 2024

Hwang Inwoo, Cho Yunjoo, Kang So Young, Kim Deok Geun, Ahn Soomin, Lee Jeeyun, Kim Kyoung-Mee

Abstract excerpt

The ARID1A gene is pivotal in chromatin remodeling and genomic integrity and is frequently mutated in various cancer types. ARID1A mutation is the second most frequently mutated tumor suppressor gene and has been suggested as a predictor of immunotherapeutic responsiveness in gastric carcinoma (GC). Despite its significance, the relationship among ARID1A somatic mutations, RNA expression levels, and protein...

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PMID: 38324965
DOI: 10.1016/j.prp.2023.155063

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