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Article

Allelic expression imbalance of JAK2 V617F mutation in BCR-ABL negative myeloproliferative neoplasms.

PloS one - 1 Jan 2013

Kim Hye-Ran, Choi Hyun-Jung, Kim Yeo-Kyeoung, Kim Hyeoung-Joon, Shin Jong-Hee, Suh Soon-Pal, Ryang Dong-Wook, Shin Myung-Geun

Abstract excerpt

The discovery of a single point mutation in the JAK2 gene in patients with BCR/ABL-negative myeloproliferative neoplasms (MPNs) has not only brought new insights and pathogenesis, but also has made the diagnosis of MPNs much easier. Although, to date, several mechanisms for the contribution of single JAK2V617F point mutation to phenotypic diversity of MPNs have been suggested in multiple studies, but it is not...

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Share to Disease Progression
Share to Fusion Proteins, bcr-abl

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23349688
DOI: 10.1371/journal.pone.0052518
PMCID: PMC3551963

Genes

JAK2
BCR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Allelic expression imbalance of JAK2 V617F mutation in BCR-ABL negative myeloproliferative neoplasms.PMID 23349688Read ↗

Clinical correlates of JAK2V617F presence or allele burden in myeloproliferative neoplasms: a critical reappraisal.Semantic proximity Read ↗

The Combination of JAK2V617F Allele Burden and WT1 Expression can Be Helpful in Distinguishing the Subtype of MPN Patients.Semantic proximity Read ↗

JAK2V617F allele burden in patients with myeloproliferative neoplasms.Semantic proximity Read ↗

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Impact of JAK2 V617F mutation on hemogram variation in patients with non-reactive elevated platelet counts.Semantic proximity Read ↗

[Correlation between JAK2-V617F mutations and variation of peripheral blood cells among BCR/ABL-negative MPD patients].Semantic proximity Read ↗

[A novel quantitative JAK2V617F detection kit: prospective clinical performance study comparing MPN patients and healthy subjects].Semantic proximity Read ↗

[The investigation of JAK2 V617F point mutation in myeloproliferative disorders by allele-specific polymerase chain reaction in combination with sequence analysis].Semantic proximity Read ↗

Transcriptional differences between JAK2-V617F and wild-type bone marrow cells in patients with myeloproliferative neoplasms.Semantic proximity Read ↗

Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice.Semantic proximity Read ↗

[Usefulness of real-time semi-quantitative PCR, JAK2 MutaScreen kit for JAK2 V617F screening].Semantic proximity Read ↗

[The clinical implication of JAK2 mutation expression in patients with myeloproliferative disorders].Semantic proximity Read ↗

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