Article
An epigenetic feedback regulatory loop involving microRNA-195 and MBD1 governs neural stem cell differentiation.
PloS one - 1 Jan 2013
Liu Changmei, Teng Zhao-Qian, McQuate Andrea L, Jobe Emily M, Christ Christa C, von Hoyningen-Huene Sergei J, Reyes Marie D, Polich Eric D, Xing Yina, Li Yue, Guo Weixiang, Zhao Xinyu
Abstract excerpt
BACKGROUND: Epigenetic mechanisms, including DNA methylation, histone modification, and microRNAs, play pivotal roles in stem cell biology. Methyl-CpG binding protein 1 (MBD1), an important epigenetic regulator of adult neurogenesis, controls the proliferation and differentiation of adult neural...
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