Article
Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia.
Haematologica - 1 Apr 2013
Tiacci Enrico, Schiavoni Gianluca, Martelli Maria Paola, Boveri Emanuela, Pacini Roberta, Tabarrini Alessia, Zibellini Silvia, Santi Alessia, Pettirossi Valentina, Fortini Elisabetta, Ascani Stefano, Arcaini Luca, Inghirami Giorgio, Paulli Marco, Falini Brunangelo
Abstract excerpt
The BRAF-V600E mutation defines genetically hairy cell leukemia among B-cell leukemias and lymphomas. In solid tumors, BRAF-V600E is known to aberrantly activate the oncogenic MEK-ERK pathway, and targeted BRAF and/or MEK inhibitors have shown remarkable efficacy in clinical trials in melanoma pa...
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