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Article

Reduced mitochondrial DNA copy number in peripheral blood leukocytes increases the risk of soft tissue sarcoma.

Carcinogenesis - 1 May 2013

Xie Hui, Lev Dina, Gong Yilei, Wang Shui, Pollock Raphael E, Wu Xifeng, Gu Jian

Abstract excerpt

Mitochondrial DNA (mtDNA) has increased susceptibility to damage due to its close proximity to the site of reactive oxygen species production, lack of introns and protective histones, and less efficient DNA repair mechanisms than nuclear DNA. The relationship between mtDNA copy number in peripheral blood leukocytes (PBLs) and the risk of soft tissue sarcoma (STS) has not been investigated. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23349016
DOI: 10.1093/carcin/bgt023

Genes

STS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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