Article
Lack of tailless leads to an increase in expression variability in Drosophila embryos.
Developmental biology - 1 May 2013
Janssens Hilde, Crombach Anton, Wotton Karl Richard, Cicin-Sain Damjan, Surkova Svetlana, Lim Chea Lu, Samsonova Maria, Akam Michael, Jaeger Johannes
Abstract excerpt
Developmental processes are robust, or canalised: dynamic patterns of gene expression across space and time are regulated reliably and precisely in the presence of genetic and environmental perturbations. It remains unclear whether canalisation relies on specific regulatory factors (such as heat-shock proteins), or whether it is based on more general redundancy and distributed robustness at the network level. The...
Topics
- Animals
- Blastoderm
- Body Patterning
- Drosophila Proteins
- Drosophila melanogaster
- Embryo, Nonmammalian
- Gene Expression Regulation, Developmental
- Gene Regulatory Networks
- Genes, Insect
- Homeodomain Proteins
- Mutation
- Repressor Proteins
- Transcription Factors