Article
Canalization of gene expression in the Drosophila blastoderm by gap gene cross regulation.
PLoS biology - 1 Mar 2009
Manu, Surkova Svetlana, Spirov Alexander V, Gursky Vitaly V, Janssens Hilde, Kim Ah-Ram, Radulescu Ovidiu, Vanario-Alonso Carlos E, Sharp David H, Samsonova Maria, Reinitz John
Abstract excerpt
Developing embryos exhibit a robust capability to reduce phenotypic variations that occur naturally or as a result of experimental manipulation. This reduction in variation occurs by an epigenetic mechanism called canalization, a phenomenon which has resisted understanding because of a lack of necessary molecular data and of appropriate gene regulation models. In recent years, quantitative gene expression data...
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