Article
Env gene expression of human endogenous retrovirus-k and human endogenous retrovirus-w in childhood acute leukemia cells.
Acta haematologica - 1 Jan 2013
Januszkiewicz-Lewandowska Danuta, Nowicka Karina, Rembowska Jolanta, Fichna Marta, Żurawek Magda, Derwich Katarzyna, Nowak Jerzy
Abstract excerpt
INTRODUCTION: The etiopathogenesis of childhood leukemia is not fully understood. It is suggested that endogenous viral sequences may play a role in leukemogenesis. Human endogenous retroviruses (HERVs) constitute about 8% of the human genome. Most HERVs are dysfunctional because of numerous mutations and deletions. Some HERVs, however, contain sequences capable of transcription. In patients with leukemia, the...
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