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Article

Use of somatic mutations to quantify random contributions to mouse development.

BMC genomics - 18 Jan 2013

Zhou Wenyu, Tan Yunbing, Anderson Donovan J, Crist Eva M, Ruohola-Baker Hannele, Salipante Stephen J, Horwitz Marshall S

Abstract excerpt

BACKGROUND: The C. elegans cell fate map, in which the lineage of its approximately 1000 cells is visibly charted beginning from the zygote, represents a developmental biology milestone. Nematode development is invariant from one specimen to the next, whereas in mammals, aspects of development are probabilistic, and development exhibits variation between even genetically identical individuals. Consequently, a...

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PMID: 23327737
DOI: 10.1186/1471-2164-14-39
PMCID: PMC3564904

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