Article
Adherence and variability in warfarin dose requirements: assessment in a prospective cohort.
Pharmacogenomics - 1 Jan 2013
Jorgensen Andrea L, Hughes Dyfrig A, Hanson Anita, van Eker Diane, Toh Cheng Hock, Pirmohamed Munir, Williamson Paula R
Abstract excerpt
AIM: Although several genetic and nongenetic factors are associated with warfarin dose, approximately 40% of variability remains unexplained. An as yet unexplored factor is medication adherence. Here, we investigate the influence of adherence on response to warfarin and on pharmacogenetic analyses of association. PATIENTS & METHODS: A total of 311 patients starting warfarin were followed-up prospectively, and...
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