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Article

Expression of inhibin-alpha is regulated synergistically by Wilms' tumor gene 1 (Wt1) and steroidogenic factor-1 (Sf1) in sertoli cells.

PloS one - 1 Jan 2013

Ji Shao-Yang, Hao Jian-Xiu, Li Lei, Zhang Jun, Zheng Qiao-Song, Li Xi-Xia, Wang Xiao-Na, Han Chun-Sheng, Gao Fei, Liu Yi-Xun

Abstract excerpt

Wt1 encodes a zinc finger nuclear transcriptional factor, which is specifically expressed in testicular Sertoli cells and knockdown of Wt1 in Sertoli cells causes male mice subfertility. However, the underlying mechanism is still unclear. In this study, we found that expression of inhibin-α is significantly reduced in Wt1-deficient Sertoli cells. Luciferase assays using the inhibin-α promoter indicated that the...

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Identifiers

PMID: 23326390
DOI: 10.1371/journal.pone.0053140
PMCID: PMC3543449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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