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Article

FOXO1/3 depletion in granulosa cells alters follicle growth, death and regulation of pituitary FSH.

Molecular endocrinology (Baltimore, Md.) - 1 Feb 2013

Liu Zhilin, Castrillon Diego H, Zhou Wei, Richards Joanne S

Abstract excerpt

The Forkhead boxO (FOXO) transcription factors regulate multiple cellular functions. FOXO1 and FOXO3 are highly expressed in granulosa cells of ovarian follicles. Selective depletion of the Foxo1 and Foxo3 genes in granulosa cells of mice reveals a novel ovarian-pituitary endocrine feedback loop...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23322722
DOI: 10.1210/me.2012-1296
PMCID: PMC3683807

Genes

FOXO1
BMP2
FOXO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23322722-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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FOXO1/3 depletion in granulosa cells alters follicle growth, death and regulation of pituitary FSH.PMID 23322722Read ↗

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The ovary: basic biology and clinical implicationsSemantic proximity Read ↗

miR‐221‐3p regulates apoptosis of ovarian granulosa cells via targeting FOXO1 in older women with diminished ovarian reserve (DOR)Semantic proximity Read ↗

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SMAD4 Inhibits Granulosa Cell Apoptosis via the miR-183-96-182 Cluster and FoxO1 AxisSemantic proximity Read ↗

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