Article
PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.
Cancer research - 1 Jul 2012
Keng Vincent W, Rahrmann Eric P, Watson Adrienne L, Tschida Barbara R, Moertel Christopher L, Jessen Walter J, Rizvi Tilat A, Collins Margaret H, Ratner Nancy, Largaespada David A
Abstract excerpt
The genetic evolution from a benign neurofibroma to a malignant sarcoma in patients with neurofibromatosis type 1 (NF1) syndrome remains unclear. Schwann cells and/or their precursor cells are believed to be the primary pathogenic cell in neurofibromas because they harbor biallelic neurofibromin...
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