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Article

Snapshots of a protein folding intermediate.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jan 2013

Yamada Seiji, Bouley Ford Nicole D, Keller Gretchen E, Ford William C, Gray Harry B, Winkler Jay R

Abstract excerpt

We have investigated the folding dynamics of Thermus thermophilus cytochrome c(552) by time-resolved fluorescence energy transfer between the heme and each of seven site-specific fluorescent probes. We have found both an equilibrium unfolding intermediate and a distinct refolding intermediate from kinetics studies. Depending on the protein region monitored, we observed either two-state or three-state denaturation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23319660
DOI: 10.1073/pnas.1221832110
PMCID: PMC3562762

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