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Article

Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer.

International journal of cancer - 15 Jul 2013

Heitzer Ellen, Auer Martina, Hoffmann Eva Maria, Pichler Martin, Gasch Christin, Ulz Peter, Lax Sigurd, Waldispuehl-Geigl Julie, Mauermann Oliver, Mohan Sumitra, Pristauz Gunda, Lackner Carolin, Höfler Gerald, Eisner Florian, Petru Edgar, Sill Heinz, Samonigg Hellmut, Pantel Klaus, Riethdorf Sabine, Bauernhofer Thomas, Geigl Jochen B, Speicher Michael R

Abstract excerpt

With the increasing number of available predictive biomarkers, clinical management of cancer is becoming increasingly reliant on the accurate serial monitoring of tumor genotypes. We tested whether tumor-specific copy number changes can be inferred from the peripheral blood of patients with cancer. To this end, we determined the plasma DNA size distribution and the fraction of mutated plasma DNA fragments with...

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Identifiers

PMID: 23319339
DOI: 10.1002/ijc.28030
PMCID: PMC3708119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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