Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Strategic applications of gene expression: from drug discovery/development to bedside.

The AAPS journal - 1 Apr 2013

Bai Jane P F, Alekseyenko Alexander V, Statnikov Alexander, Wang I-Ming, Wong Peggy H

Abstract excerpt

Gene expression is useful for identifying the molecular signature of a disease and for correlating a pharmacodynamic marker with the dose-dependent cellular responses to exposure of a drug. Gene expression offers utility to guide drug discovery by illustrating engagement of the desired cellular p...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Discovery
Share to Drug-Related Side Effects and Adverse Reactions
Share to Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Targeted Therapy

Share to Patient Selection

Share to Precision Medicine

Share to Predictive Value of Tests

Share to Translational Research, Biomedical

Source

Open in PubMed Open full text

Identifiers

PMID: 23319288
DOI: 10.1208/s12248-012-9447-1
PMCID: PMC3675744

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23319288-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Strategic applications of gene expression: from drug discovery/development to bedside.PMID 23319288Read ↗

Expression genomics and drug development: towards predictive pharmacology.Semantic proximity Read ↗

Cancer gene expression signatures - the rise and fall?Semantic proximity Read ↗

Systematic Analysis of Drug Targets Confirms Expression in Disease-Relevant Tissues.Semantic proximity Read ↗

Mining gene expression profiles: expression signatures as cancer phenotypes.Semantic proximity Read ↗

Gene expression microarray technologies in the development of new therapeutic agents.Semantic proximity Read ↗

Transcriptional data: a new gateway to drug repositioning?Semantic proximity Read ↗

Gene-signature-derived IC50s/EC50s reflect the potency of causative upstream targets and downstream phenotypes.Semantic proximity Read ↗

From Traditional Biomarkers to Transcriptome Analysis in Drug DevelopmentSemantic proximity Read ↗

Harnessing AI to fuse phenotypic signatures for drug target identification: progress in computational modeling.Semantic proximity Read ↗

Identification of phenotype deterministic genes using systemic analysis of transcriptional response.Semantic proximity Read ↗

Use of traditional end points and gene dysregulation to understand mechanisms of toxicity: toxicogenomics in mechanistic toxicology.Semantic proximity Read ↗

Novel strategies for therapeutic design in molecular oncology using gene expression profiles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.