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Article

Association of MTHFR C677T polymorphism with schizophrenia and its effect on episodic memory and gray matter density in patients.

Behavioural brain research - 15 Apr 2013

Zhang Yanling, Yan Hao, Tian Lin, Wang Fang, Lu Tianlan, Wang Lifang, Yan Jun, Liu Qi, Kang Lan, Ruan Yanyan, Zhang Dai, Yue Weihua

Abstract excerpt

Growing evidence suggests that the methylenetetrahydrofolate reductase (MTHFR) may play a role in the pathogenesis of schizophrenia. Recent studies suggested that the MTHFR 677T, as a risk allele, has an impact on brain activation and memory function in schizophrenia patients. To confirm further...

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Source

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Identifiers

PMID: 23318463
DOI: 10.1016/j.bbr.2012.12.061
PMCID: PMC3755007

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23318463-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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