Article
Importance of different types of prior knowledge in selecting genome-wide findings for follow-up.
Genetic epidemiology - 1 Feb 2013
Minelli Cosetta, De Grandi Alessandro, Weichenberger Christian X, Gögele Martin, Modenese Mirko, Attia John, Barrett Jennifer H, Boehnke Michael, Borsani Giuseppe, Casari Giorgio, Fox Caroline S, Freina Thomas, Hicks Andrew A, Marroni Fabio, Parmigiani Giovanni, Pastore Andrea, Pattaro Cristian, Pfeufer Arne, Ruggeri Fabrizio, Schwienbacher Christine, Taliun Daniel, Pramstaller Peter P, Domingues Francisco S, Thompson John R
Abstract excerpt
Biological plausibility and other prior information could help select genome-wide association (GWA) findings for further follow-up, but there is no consensus on which types of knowledge should be considered or how to weight them. We used experts' opinions and empirical evidence to estimate the relative importance of 15 types of information at the single-nucleotide polymorphism (SNP) and gene levels. Opinions were...
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