Article
fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2013
Yutsudo Noriko, Kamada Takashi, Kajitani Kosuke, Nomaru Hiroko, Katogi Atsuhisa, Ohnishi Yoko H, Ohnishi Yoshinori N, Takase Kei-ichiro, Sakumi Kunihiko, Shigeto Hiroshi, Nakabeppu Yusaku
Abstract excerpt
Patients with epilepsy are at high risk for major depression relative to the general population, and both disorders are associated with changes in adult hippocampal neurogenesis, although the mechanisms underlying disease onset remain unknown. The expression of fosB, an immediate early gene encoding FosB and ΔFosB/Δ2ΔFosB by alternative splicing and translation initiation, is known to be induced in neural...
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