Article
Association of single nucleotide polymorphisms in TCF2 with type 2 diabetes susceptibility in a Han Chinese population.
PloS one - 1 Jan 2012
Zhang Xuelong, Qiao Hong, Zhao Yanling, Wang Xi, Sun Haiming, Liu An, Xu Lidan, Sun Donglin, Jin Yan, Yu Yang, Meng Xiangning, Bai Jing, Chen Feng, Fu Songbin
Abstract excerpt
Hepatocyte nuclear factor 1β (HNF1β), a transcription factor encoded by the transcription factor 2 gene (TCF2), plays a critical role in pancreatic cell formation and glucose homeostasis. It has been suggested that single nucleotide polymorphisms (SNPs) of TCF2 are associated with susceptibility to type 2 diabetes (T2D). However, published results are inconsistent and inclusive. To further investigate the role of...
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