Contribution of copy number variations to education, socioeconomic status and cognition from a genome-wide study of 305,401 subjects.

doi:10.1038/s41380-024-02717-z

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Article

Contribution of copy number variations to education, socioeconomic status and cognition from a genome-wide study of 305,401 subjects.

Molecular psychiatry - 1 Mar 2025

Wu Xin-Rui, Wu Bang-Sheng, Kang Ju-Jiao, Chen Li-Min, Deng Yue-Ting, Chen Shi-Dong, Dong Qiang, Feng Jian-Feng, Cheng Wei, Yu Jin-Tai

Abstract excerpt

Educational attainment (EA), socioeconomic status (SES) and cognition are phenotypically and genetically linked to health outcomes. However, the role of copy number variations (CNVs) in influencing EA/SES/cognition remains unclear. Using a large-scale (n = 305,401) genome-wide CNV-level association analysis, we discovered 33 CNV loci significantly associated with EA/SES/cognition, 20 of which were novel...

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Topics

Humans
DNA Copy Number Variations
Genome-Wide Association Study
Male
Female
Cognition

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Educational Status

Social Class

Middle Aged

Adult

Polymorphism, Single Nucleotide

Aged

Genetic Predisposition to Disease

Phenotype

Source

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Identifiers

PMID: 39215183
DOI: 10.1038/s41380-024-02717-z

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