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Article

The mechanism of toxicity in HET-S/HET-s prion incompatibility.

PLoS biology - 1 Jan 2012

Seuring Carolin, Greenwald Jason, Wasmer Christian, Wepf Roger, Saupe Sven J, Meier Beat H, Riek Roland

Abstract excerpt

The HET-s protein from the filamentous fungus Podospora anserina is a prion involved in a cell death reaction termed heterokaryon incompatibility. This reaction is observed at the point of contact between two genetically distinct strains when one harbors a HET-s prion (in the form of amyloid aggregates) and the other expresses a soluble HET-S protein (96% identical to HET-s). How the HET-s prion interaction with...

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Source

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Identifiers

PMID: 23300377
DOI: 10.1371/journal.pbio.1001451
PMCID: PMC3531502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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