Article
A yeast toxic mutant of HET-s amyloid disrupts membrane integrity.
Biochimica et biophysica acta - 1 Sept 2012
Ta Ha Phuong, Berthelot Karine, Coulary-Salin Bénédicte, Castano Sabine, Desbat Bernard, Bonnafous Pierre, Lambert Olivier, Alves Isabel, Cullin Christophe, Lecomte Sophie
Abstract excerpt
Many studies have pointed out the interaction between amyloids and membranes, and their potential involvement in amyloid toxicity. Previously, we generated a yeast toxic amyloid mutant (M8) from the harmless amyloid protein by changing a few residues of the Prion Forming Domain of HET-s (PFD HET-s(218-289)) and clearly demonstrated the complete different behaviors of the non-toxic Wild Type (WT) and toxic amyloid...
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