Proteomic Comparison of Historic and Recently Emerged Hypervirulent <i>Clostridium difficile</i> Strains

Abstract excerpt

Clostridium difficile in recent years has undergone rapid evolution and has emerged as a serious human pathogen. Proteomic approaches can improve the understanding of the diversity of this important pathogen, especially in comparing the adaptive ability of different C. difficile strains. In this study, TMT labeling and nanoLC-MS/MS driven proteomics were used to investigate the responses of four C. difficile...

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