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Article

Molecular mechanism of HIV-1 gp120 mutations that reduce CD4 binding affinity.

Journal of biomolecular structure & dynamics - 1 Jan 2014

Kassler Kristin, Sticht Heinrich

Abstract excerpt

The interaction of the HIV-1 fusion protein gp120 with its cellular receptor CD4 represents a crucial step of the viral infection process, thus rendering gp120 a promising target for the intervention with anti-HIV drugs. Naturally occurring mutations of gp120, however, can decrease its affinity f...

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Source

Identifiers

PMID: 23297802
DOI: 10.1080/07391102.2012.746946

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23297802-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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