Article
A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi.
The Journal of experimental medicine - 14 Jan 2013
Hoogeboom Robbert, van Kessel Kok P M, Hochstenbach Frans, Wormhoudt Thera A, Reinten Roy J A, Wagner Koen, Kater Arnon P, Guikema Jeroen E J, Bende Richard J, van Noesel Carel J M
Abstract excerpt
B cell chronic lymphocytic leukemia (CLL), the most common leukemia in adults, is a clonal expansion of CD5(+)CD19(+) B lymphocytes. Two types of CLLs are being distinguished as carrying either unmutated or somatically mutated immunoglobulins (Igs), which are associated with unfavorable and favorable prognoses, respectively. More than 30% of CLLs can be grouped based on their expression of stereotypic B cell...
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