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Article

Loss-of-function mutations of SOX17 lead to YAP/TEAD activation-dependent malignant transformation in endometrial cancer.

Oncogene - 1 Jan 2023

Wang Mengfei, Yan Qin, Song Yunfeng, Zhang Zhenbo, Chen Xiaojun, Gao Kun, Wan Xiaoping

Abstract excerpt

Aberrant hyperactivation of the Hippo pathway effector YAP/TEAD complex causes tissue overgrowth and tumorigenesis in various cancers, including endometrial cancer (EC). The transcription factor SOX17 (SRY [sex-determining region Y]-box 17) is frequently mutated in EC; however, SOX17 mutations are rare in other cancer types. The molecular mechanisms underlying SOX17 mutation-induced EC tumorigenesis remain poorly...

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PMID: 36446891
DOI: 10.1038/s41388-022-02550-0

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