Molecular epidemiology of levofloxacin-resistant Klebsiella pneumoniae and the association of plasmid-mediated quinolone resistance genes with key biological phenotypes.

doi:10.1128/spectrum.01031-26

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Article

Molecular epidemiology of levofloxacin-resistant Klebsiella pneumoniae and the association of plasmid-mediated quinolone resistance genes with key biological phenotypes.

Microbiology spectrum - 7 Jul 2026

Zhang Qian, Jia Xinmiao, Chen Shiyu, Jia Peiyao, Zhu Ying, Yu Wei, Chu Xiaobing, Li Zongping, Yang Qiwen

Abstract excerpt

Klebsiella pneumoniae is a major opportunistic pathogen in China, yet the molecular epidemiology of quinolone resistance remains poorly characterized. This study analyzed 2,433 clinical isolates from 37 Chinese hospitals (2018-2022). The overall levofloxacin-non-susceptible (NS) rate was 53.60%,...

Topics

Klebsiella pneumoniae
Klebsiella Infections
Plasmids
Animals
Levofloxacin
Anti-Bacterial Agents
Quinolones
Humans
China
Microbial Sensitivity Tests
Molecular Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Bacterial Proteins

Drug Resistance, Bacterial

Phenotype

Whole Genome Sequencing

Virulence

Drug Resistance, Multiple, Bacterial

Source

Open in PubMed Open full text

Identifiers

PMID: 42159499
DOI: 10.1128/spectrum.01031-26
PMCID: PMC13344114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-42159499-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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