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Article

Dose-dependent efficacy and safety toxicology of hydroxypyridinonate actinide decorporation agents in rodents: towards a safe and effective human dosing regimen.

Radiation research - 1 Feb 2013

Bunin Deborah I, Chang Polly Y, Doppalapudi Rupa S, Riccio Edward S, An Dahlia, Jarvis Erin E, Kullgren Birgitta, Abergel Rebecca J

Abstract excerpt

Two hydroxypyridinone-containing actinide decorporation agents, 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO), are being developed for the treatment of internal actinide contamination by chelation therapy. Dose-response efficacy profiles in mice were established for the removal of intravenously injected (238)Pu and (241)Am after parenteral and oral treatment with these chelators. In both cases, presumed efficacious...

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PMID: 23289385
DOI: 10.1667/RR3115.1
PMCID: PMC3633606

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