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Article

Dose-dependent efficacy and safety toxicology of hydroxypyridinonate actinide decorporation agents in rodents: towards a safe and effective human dosing regimen.

Radiation research - 1 Feb 2013

Bunin Deborah I, Chang Polly Y, Doppalapudi Rupa S, Riccio Edward S, An Dahlia, Jarvis Erin E, Kullgren Birgitta, Abergel Rebecca J

Abstract excerpt

Two hydroxypyridinone-containing actinide decorporation agents, 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO), are being developed for the treatment of internal actinide contamination by chelation therapy. Dose-response efficacy profiles in mice were established for the removal of intravenously injec...

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Identifiers

PMID: 23289385
DOI: 10.1667/RR3115.1
PMCID: PMC3633606

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23289385-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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