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Article

ASPSCR1::TFE3-mediated upregulation of insulin receptor substrate 2 (IRS-2) activates PI3K/AKT signaling and promotes malignant phenotype.

The international journal of biochemistry & cell biology - 1 Nov 2024

Ishiguro Naoko, Nakagawa Mayumi

Abstract excerpt

The ASPSCR1::TFE3 fusion gene, resulting from chromosomal translocation, is detected in alveolar soft part sarcoma (ASPS) and a subset of renal cell carcinomas (RCC). The ASPSCR1::TFE3 oncoprotein, functioning as an aberrant transcription factor, contributes to tumor development and progression by inappropriately upregulating target genes. Here, we identified insulin receptor substrate 2 (IRS-2), a cytoplasmic...

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Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin Receptor Substrate Proteins

Share to Kidney Neoplasms

Share to Oncogene Proteins, Fusion

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-akt

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Identifiers

PMID: 39419345
DOI: 10.1016/j.biocel.2024.106676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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